Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience.

doi:10.1186/s13073-017-0486-1

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Article

Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience.

Genome medicine - 29 Nov 2017

Ridge Perry G, Karch Celeste M, Hsu Simon, Arano Ivan, Teerlink Craig C, Ebbert Mark T W, Gonzalez Murcia Josue D, Farnham James M, Damato Anna R, Allen Mariet, Wang Xue, Harari Oscar, Fernandez Victoria M, Guerreiro Rita, Bras Jose, Hardy John, Munger Ronald, Norton Maria, Sassi Celeste, Singleton Andrew, Younkin Steven G, Dickson Dennis W, Golde Todd E, Price Nathan D, Ertekin-Taner Nilüfer, Cruchaga Carlos, Goate Alison M, Corcoran Christopher, Tschanz JoAnn, Cannon-Albright Lisa A, Kauwe John S K

Abstract excerpt

BACKGROUND: While age and the APOE ε4 allele are major risk factors for Alzheimer's disease (AD), a small percentage of individuals with these risk factors exhibit AD resilience by living well beyond 75 years of age without any clinical symptoms of cognitive decline. METHODS: We used over 200 "AD resilient" individuals and an innovative, pedigree-based approach to identify genetic variants that segregate with AD...

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Identifiers

PMID: 29183403
DOI: 10.1186/s13073-017-0486-1
PMCID: PMC5706401

Genes

RAB10
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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