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Article

Tamm-Horsfall protein/uromodulin deficiency elicits tubular compensatory responses leading to hypertension and hyperuricemia.

American journal of physiology. Renal physiology - 1 Jun 2018

Liu Yan, Goldfarb David S, El-Achkar Tarek M, Lieske John C, Wu Xue-Ru

Abstract excerpt

Expression of Tamm-Horsfall protein (THP or uromodulin) is highly restricted to the kidney thick ascending limb (TAL) of loop of Henle. Despite the unique location and recent association of THP gene mutations with hereditary uromodulin-associated kidney disease and THP single nucleotide polymorphisms with chronic kidney disease and hypertension, the physiological function(s) of THP and its pathological...

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Identifiers

PMID: 29357410
DOI: 10.1152/ajprenal.00233.2017
PMCID: PMC6032075

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