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Article

Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall protein.

American journal of physiology. Renal physiology - 1 Sept 2010

Liu Yan, Mo Lan, Goldfarb David S, Evan Andrew P, Liang Fengxia, Khan Saeed R, Lieske John C, Wu Xue-Ru

Abstract excerpt

Mammalian urine contains a range of macromolecule proteins that play critical roles in renal stone formation, among which Tamm-Horsfall protein (THP) is by far the most abundant. While THP is a potent inhibitor of crystal aggregation in vitro and its ablation in vivo predisposes one of the two existing mouse models to spontaneous intrarenal calcium crystallization, key controversies remain regarding the role of...

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Identifiers

PMID: 20591941
DOI: 10.1152/ajprenal.00243.2010
PMCID: PMC2944300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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