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Article

Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli.

American journal of physiology. Renal physiology - 1 Apr 2004

Mo Lan, Zhu Xin-Hua, Huang Hong-Ying, Shapiro Ellen, Hasty David L, Wu Xue-Ru

Abstract excerpt

The adhesion of uropathogenic Escherichia coli to the urothelial surface of the bladder is a prerequisite for the establishment of bladder infections. This adhesion process relies on E. coli adhesins and their cognate urothelial receptors, and it also is influenced by an intricate array of defense mechanisms of the urinary system. In this study, we examined the in vivo role of Tamm-Horsfall protein (THP), the...

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Identifiers

PMID: 14665435
DOI: 10.1152/ajprenal.00357.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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