Article
Tamm-horsfall protein protects against urinary tract infection by proteus mirabilis.
The Journal of urology - 1 May 2009
Raffi Hajamohideen S, Bates James M, Laszik Zoltan, Kumar Satish
Abstract excerpt
PURPOSE: Proteus mirabilis is a common cause of urinary tract infection. We determined the role of Tamm-Horsfall protein as a host defense factor against the cystitis and pyelonephritis caused by P. mirabilis. MATERIALS AND METHODS: We generated Tamm-Horsfall protein gene knockout mice using homologous recombination. We introduced P. mirabilis transurethrally into the bladder of Tamm-Horsfall protein deficient...
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