Article

Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing

2020-07-13

Abstract excerpt

Genome editing has promising therapeutic potential for genetic diseases and cancer (1, 2). However, the most practicable current approaches rely on the generation of DNA double-strand breaks (DSBs), which can give rise to a poorly characterized spectrum of structural chromosomal abnormalities. Here, we show that a catastrophic mutational process called chromothripsis is a previously unappreciated consequence of CR...

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Literature Corpus work: 2c7c42a4-308c-5104-b4cc-d754e2139a6a
DOI: 10.1101/2020.07.13.200998

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