Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Temporal ordering of substitutions in RNA evolution: Uncovering the structural evolution of the Human Accelerated Region 1.

Journal of theoretical biology - 7 Feb 2018

Walter Costa Maria Beatriz, Höner Zu Siederdissen Christian, Tulpan Dan, Stadler Peter F, Nowick Katja

Abstract excerpt

The Human Accelerated Region 1 (HAR1) is the most rapidly evolving region in the human genome. It is part of two overlapping long non-coding RNAs, has a length of only 118 nucleotides and features 18 human specific changes compared to an ancestral sequence that is extremely well conserved across non-human primates. The human HAR1 forms a stable secondary structure that is strikingly different from the one in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evolution, Molecular
Share to Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Nucleic Acid Conformation

Share to Probability

Share to RNA, Untranslated

Share to Time Factors

Source

Identifiers

PMID: 29175608
DOI: 10.1016/j.jtbi.2017.11.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Temporal ordering of substitutions in RNA evolution: Uncovering the structural evolution of the Human Accelerated Region 1.PMID 29175608Read ↗

Analysis of human accelerated DNA regions using archaic hominin genomes.Semantic proximity Read ↗

Adaptive loss of function accelerated the evolution of ancient and modern human cognitionSemantic proximity Read ↗

Rapid evolution of BRCA1 and BRCA2 in humans and other primates.Semantic proximity Read ↗

Uncovering adaptive evolution in the human lineage.Semantic proximity Read ↗

Machine-learning dissection of Human Accelerated Regions in primate neurodevelopmentSemantic proximity Read ↗

Positive selection and rates of evolution in immunodeficiency viruses from humans and chimpanzees.Semantic proximity Read ↗

Estimating time-varying selection coefficients from time series data of allele frequenciesSemantic proximity Read ↗

Transcription factor binding sites are frequently under accelerated evolution in primatesSemantic proximity Read ↗

Developmental loci harbor clusters of accelerated regions that evolved independently in ape lineagesSemantic proximity Read ↗

Temporal trails of natural selection in human mitogenomes.Semantic proximity Read ↗

Rapid detection of positive selection in genes and genomes through variation clusters.Semantic proximity Read ↗

Effects of purifying and adaptive selection on regional variation in human mtDNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.