Article
Temporal trails of natural selection in human mitogenomes.
Molecular biology and evolution - 1 Apr 2009
Subramanian Sankar
Abstract excerpt
Mildly deleterious mutations initially contribute to the diversity of a population, but later they are selected against at high frequency and are eliminated eventually. Using over 1,500 complete human mitochondrial genomes along with those of Neanderthal and Chimpanzee, I provide empirical evidence for this prediction by tracing the footprints of natural selection over time. The results show a highly significant...
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