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Article

Effects of purifying and adaptive selection on regional variation in human mtDNA.

Science (New York, N.Y.) - 9 Jan 2004

Ruiz-Pesini Eduardo, Mishmar Dan, Brandon Martin, Procaccio Vincent, Wallace Douglas C

Abstract excerpt

A phylogenetic analysis of 1125 global human mitochondrial DNA (mtDNA) sequences permitted positioning of all nucleotide substitutions according to their order of occurrence. The relative frequency and amino acid conservation of internal branch replacement mutations was found to increase from tro...

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Identifiers

PMID: 14716012
DOI: 10.1126/science.1088434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14716012-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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