Article
Positive selection and rates of evolution in immunodeficiency viruses from humans and chimpanzees.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 1996
Mindell D P
Abstract excerpt
Evolutionary theory predicts the recent spread of primate immunodeficiency viruses (PIVs) to new human populations to be accompanied by positive selection in response to new host environments and/or by random genetic drift. I assess evidence for positive selection in human and chimpanzee PIVs type I (PIV1s), using ratios of synonymous to nonsynonymous nucleotide change based on branch lengths and outgroup...
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