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Article

Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer.

Experimental cell research - 15 Jan 2018

Fang Xiao, Lu Guojun, Ha Kyungsoo, Lin Han, Du Ye, Zuo Qiuhong, Fu Yi, Zou Chaoxia, Zhang Pumin

Abstract excerpt

Tumor cells often encounter hypoglycemic microenvironment due to rapid cell expansion. It remains elusive how tumors reprogram the genome to survive the metabolic stress. The tumor suppressor TIP60 functions as the catalytic subunit of the human NuA4 histone acetyltransferase (HAT) multi-subunit complex and is involved in many different cellular processes including DNA damage response, cell growth and apoptosis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

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Source

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Identifiers

PMID: 29174981
DOI: 10.1016/j.yexcr.2017.11.028
PMCID: PMC6360337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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