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Article

PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy.

Cell cycle (Georgetown, Tex.) - 15 Jul 2012

Naidu Samisubbu R, Lakhter Alexander J, Androphy Elliot J

Abstract excerpt

Posttranslational modifications of p53 integrate diverse stress signals and regulate its activity, but their combinatorial contribution to overall p53 function is not clear. We investigated the roles of lysine (K) acetylation and sumoylation on p53 and their relation to apoptosis and autophagy. Here we describe the collaborative role of the SUMO E3 ligase PIASy and the lysine acetyltransferase Tip60 in...

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Source

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Identifiers

PMID: 22751435
DOI: 10.4161/cc.21091
PMCID: PMC3409012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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