Article
Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density.
Annals of the rheumatic diseases - 1 Mar 2018
Alonso Nerea, Estrada Karol, Albagha Omar M E, Herrera Lizbeth, Reppe Sjur, Olstad Ole K, Gautvik Kaare M, Ryan Niamh M, Evans Kathryn L, Nielson Carrie M, Hsu Yi-Hsiang, Kiel Douglas P, Markozannes George, Ntzani Evangelia E, Evangelou Evangelos, Feenstra Bjarke, Liu Xueping, Melbye Mads, Masi Laura, Brandi Maria Luisa, Riches Philip, Daroszewska Anna, Olmos José Manuel, Valero Carmen, Castillo Jesús, Riancho José A, Husted Lise B, Langdahl Bente L, Brown Matthew A, Duncan Emma L, Kaptoge Stephen, Khaw Kay-Tee, Usategui-Martín Ricardo, Del Pino-Montes Javier, González-Sarmiento Rogelio, Lewis Joshua R, Prince Richard L, D'Amelio Patrizia, García-Giralt Natalia, Nogués Xavier, Mencej-Bedrac Simona, Marc Janja, Wolstein Orit, Eisman John A, Oei Ling, Medina-Gómez Carolina, Schraut Katharina E, Navarro Pau, Wilson James F, Davies Gail, Starr John, Deary Ian, Tanaka Toshiko, Ferrucci Luigi, Gianfrancesco Fernando, Gennari Luigi, Lucas Gavin, Elosua Roberto, Uitterlinden André G, Rivadeneira Fernando, Ralston Stuart H
Abstract excerpt
OBJECTIVES: To identify genetic determinants of susceptibility to clinical vertebral fractures, which is an important complication of osteoporosis. METHODS: Here we conduct a genome-wide association study in 1553 postmenopausal women with clinical vertebral fractures and 4340 controls, with a two-stage replication involving 1028 cases and 3762 controls. Potentially causal variants were identified using expression...
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