Article
Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 2014
Liu Mohan, Goss Paul E, Ingle James N, Kubo Michiaki, Furukawa Yoichi, Batzler Anthony, Jenkins Gregory D, Carlson Erin E, Nakamura Yusuke, Schaid Daniel J, Chapman Judy-Anne W, Shepherd Lois E, Ellis Matthew J, Khosla Sundeep, Wang Liewei, Weinshilboum Richard M
Abstract excerpt
Bone fractures are a major consequence of osteoporosis. There is a direct relationship between serum estrogen concentrations and osteoporosis risk. Aromatase inhibitors (AIs) greatly decrease serum estrogen levels in postmenopausal women, and increased incidence of fractures is a side effect of AI therapy. We performed a discovery case-cohort genome-wide association study (GWAS) using samples from 1071 patients,...
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