Article

GWAS of ∼30,000 samples with bone mineral density at multiple skeletal sites and its clinical relevance on fracture prediction, genetic correlations and prioritization of drug targets

2024-01-20

Abstract excerpt

We conducted genome-wide association studies (GWAS) of dual-energy X-ray absorptiometry (DXA)-derived bone mineral density (BMD) traits at 11 skeletal sites, within over 30,000 European individuals from the UK Biobank. A total of 92 unique and independent loci were identified for 11 DXA-derived BMD traits and fracture, including five novel loci (harboring genes such as ABCA1 , CHSY1 , CYP24A1 , SWAP70 , and PAX1 )...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e899c693-58a6-51a9-9a04-ccc8ff70e2b7
DOI: 10.1101/2024.01.18.24301465

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GWAS of ∼30,000 samples with bone mineral density at multiple skeletal sites and its clinical relevance on fracture prediction, genetic correlations and prioritization of drug targetsDOI 10.1101/2024.01.18.24301465Read

Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance.Semantic proximity Read

Exome-wide screening identifies novel rare risk variants for bone mineral density.Semantic proximity Read

An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.Semantic proximity Read

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.Semantic proximity Read

Prediction of Bone Mineral Density and Fragility Fracture by Genetic ProfilingSemantic proximity Read

Identifying Rare Genetic Determinants for Improved Polygenic Risk Prediction of Bone Mineral Density and Fracture Risk.Semantic proximity Read

The genetics of osteoporosis.Semantic proximity Read

Genome-wide association of an integrated osteoporosis-related phenotype: is there evidence for pleiotropic genes?Semantic proximity Read

Genome-wide polygenic risk score for major osteoporotic fractures in postmenopausal women using associated single nucleotide polymorphisms.Semantic proximity Read

Genetics of osteoporosis from genome-wide association studies: advances and challenges.Semantic proximity Read

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.Semantic proximity Read

Genome-wide association meta-analyses identified 1q43 and 2q32.2 for hip Ward's triangle areal bone mineral density.Semantic proximity Read