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Article

Association of p16 (CDKN2A) polymorphisms with the development of HPV16-related precancerous lesions and cervical cancer in the Greek population.

Journal of medical virology - 1 May 2018

Tsakogiannis Dimitris, Moschonas George D, Bella Evangelia, Kyriakopoulou Zaharoula, Amoutzias Grigoris D, Dimitriou Tilemachos G, Kottaridi Christine, Markoulatos Panayotis

Abstract excerpt

The tumor suppressor protein p16 plays a fundamental role in cell cycle regulation and exerts a protective effect against tumor growth. Two different polymorphisms at positions 540 and 580 at the 3'UTR of exon 3 of p16 gene are implicated in several types of cancer, while their role in cervical cancer development remains rather vague. In the present study, we investigated for the impact of p16...

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PMID: 29168898
DOI: 10.1002/jmv.24996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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