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Article

An upward trend in DNA p16ink4a methylation pattern and high risk HPV infection according to the severity of the cervical lesion.

Revista do Instituto de Medicina Tropical de Sao Paulo - 1 Jan 2000

Carestiato Fernanda Nahoum, Afonso Larissa Alves, Moysés Natalia, Almeida Filho Gutemberg Leão, Velarde Luis Guillermo Coca, Cavalcanti Silvia Maria Baeta

Abstract excerpt

High-risk human papillomavirus (hr-HPV) infection is necessary but not sufficient for cervical cancer development. Recently, P16INK4A gene silencing through hypermethylation has been proposed as an important cofactor in cervical carcinogenesis due to its tumor suppressor function. We aimed to investigate P16INK4A methylation status in normal and neoplastic epithelia and evaluate an association with HPV infection...

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Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Uterine Cervical Dysplasia

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Source

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Identifiers

PMID: 24037287
DOI: 10.1590/S0036-46652013000500006
PMCID: PMC4105070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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