Article
Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.
PLoS genetics - 1 Apr 2021
Gormley Mark, Yarmolinsky James, Dudding Tom, Burrows Kimberley, Martin Richard M, Thomas Steven, Tyrrell Jessica, Brennan Paul, Pring Miranda, Boccia Stefania, Olshan Andrew F, Diergaarde Brenda, Hung Rayjean J, Liu Geoffrey, Legge Danny, Tajara Eloiza H, Severino Patricia, Lacko Martin, Ness Andrew R, Davey Smith George, Vincent Emma E, Richmond Rebecca C
Abstract excerpt
Head and neck squamous cell carcinoma (HNSCC), which includes cancers of the oral cavity and oropharynx, is a cause of substantial global morbidity and mortality. Strategies to reduce disease burden include discovery of novel therapies and repurposing of existing drugs. Statins are commonly prescribed for lowering circulating cholesterol by inhibiting HMG-CoA reductase (HMGCR). Results from some observational...
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