Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study.

doi:10.1038/s41416-024-02900-7

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Article

Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study.

British journal of cancer - 1 Jan 2025

Chan Wing Ching, Liu Lili, Bouras Emmanouil, Zuber Verena, Wen Wanqing, Long Jirong, Gill Dipender, Murphy Neil, Gunter Marc J, Assimes Themistocles L, Bujanda Luis, Gruber Stephen B, Küry Sébastien, Lynch Brigid M, Qu Conghui, Thomas Minta, White Emily, Woods Michael O, Peters Ulrike, Li Christopher I, Chan Andrew T, Brenner Hermann, Tsilidis Konstantinos K, Zheng Wei

Abstract excerpt

BACKGROUND: Whether blood lipids are causally associated with colorectal cancer (CRC) risk remains unclear. METHODS: Using two-sample Mendelian randomisation (MR), our study examined the associations of genetically-predicted blood concentrations of lipids and lipoproteins (primary: LDL-C, HDL-C, triglycerides, and total cholesterol), and genetically-proxied inhibition of HMGCR, NPC1L1, and PCSK9 (which mimic...

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Identifiers

PMID: 39580580
DOI: 10.1038/s41416-024-02900-7
PMCID: PMC11723917

Genes

HMGCR
NPC1L1
PCSK9

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