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Article

Human-Specific Mutations and Positively Selected Sites in MARCO Confer Functional Changes.

Molecular biology and evolution - 1 Feb 2018

Novakowski Kyle E, Yap Nicholas V L, Yin Charles, Sakamoto Kaori, Heit Bryan, Golding G Brian, Bowdish Dawn M E

Abstract excerpt

Macrophage Receptor with COllagenous structure (MARCO) is a class A scavenger receptor that binds, phagocytoses, and modifies inflammatory responses to bacterial pathogens. Multiple candidate gene approach studies have shown that polymorphisms in MARCO are associated with susceptibility or resistance to Mycobacterium tuberculosis infection, but how these variants alter function is not known. To complement...

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Identifiers

PMID: 29165618
DOI: 10.1093/molbev/msx298
PMCID: PMC5850514

Genes

MARCO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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