Article
Functional changes in scavenger receptor binding conformation are induced by charge mutants spanning the entire collagen domain.
The Journal of biological chemistry - 31 Jul 1998
Andersson L, Freeman M W
Abstract excerpt
Macrophage scavenger receptors are trimeric integral membrane proteins that bind a diverse array of negatively charged ligands. They have been shown to play a role in the pathogenesis of atherosclerosis and in host responses to microbial infections. Earlier mutational studies demonstrated that th...
Topics
- Amino Acid Sequence
- Animals
- COS Cells
- Collagen
- Glycosylation
- Ligands
- Lipoproteins, LDL
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Conformation
- Receptors, Immunologic
- Receptors, Lipoprotein
- Receptors, Scavenger
- Recombinant Fusion Proteins
- Scavenger Receptors, Class B
- Temperature