Article
Variable responses of formyl peptide receptor haplotypes toward bacterial peptides.
Immunogenetics - 1 Feb 2008
Gripentrog Jeannie M, Mills John S, Saari George J, Miettinen Heini M
Abstract excerpt
The chemoattractant neutrophil formyl peptide receptor (FPR) binds bacterial and mitochondrial N-formylated peptides, which allows the neutrophils to find the bacterial source and/or site of tissue damage. Certain inflammatory disorders may be due in part to an impaired innate immune system that does not respond to acute bacterial damage in a timely fashion. Because the human FPR is encoded by a large number of...
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