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Article

Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution.

PloS one - 1 Jan 2011

Gorlatova Natalia, Chao Kinlin, Pal Lipika R, Araj Rawan Hanna, Galkin Andrey, Turko Illarion, Moult John, Herzberg Osnat

Abstract excerpt

High throughput genome wide associations studies (GWAS) are now identifying a large number of genome loci related to risk of common human disease. Each such locus presents a challenge in identifying the relevant underlying mechanism. Here we report the experimental characterization of a proposed causal single nucleotide polymorphism (SNP) in a locus related to risk of Crohn's disease and ulcerative colitis. The...

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PMID: 22087277
DOI: 10.1371/journal.pone.0027269
PMCID: PMC3210151

Genes

MST1
SPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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