Article
Genetic variation in the scavenger receptor MARCO and its association with chronic obstructive pulmonary disease and lung infection in 10,604 individuals.
Respiration; international review of thoracic diseases - 1 Jan 2013
Thomsen Mette, Nordestgaard Børge G, Kobzik Lester, Dahl Morten
Abstract excerpt
BACKGROUND: MARCO (macrophage receptor with collagenous structure) is a dominant receptor for unopsonized particles and bacteria in the lungs. Reduced function of this receptor due to genetic variation may be associated with susceptibility to chronic obstructive pulmonary disease (COPD) and lung infection. OBJECTIVES: To identify novel genetic variants in MARCO that are associated with reduced lung function, or...
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