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Article

COPD is associated with a macrophage scavenger receptor-1 gene sequence variation.

Chest - 1 May 2010

Ohar Jill A, Hamilton Raymond F, Zheng Siqun, Sadeghnejad Alireza, Sterling David A, Xu Jianfeng, Meyers Deborah A, Bleecker Eugene R, Holian Andrij

Abstract excerpt

BACKGROUND: Macrophages play an important role in COPD. We genotyped at-risk smokers to evaluate the role of polymorphisms in the macrophage scavenger receptor-1 gene (MSR1) in COPD susceptibility and related measures of lung function. Then, in macrophages from donors with specific MSR1 genotypes, we determined the effect of MSR1 single nucleotide polymorphisms (SNPs) on macrophage function by examining in vitro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forced Expiratory Volume

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Source

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Identifiers

PMID: 20081102
DOI: 10.1378/chest.09-1655
PMCID: PMC2862400

Genes

MSR1
FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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