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Article

Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction.

The Journal of biological chemistry - 15 Mar 1996

Kaptein A, Paillard V, Saunders M

Abstract excerpt

Interleukin-6 (IL-6) induces tyrosine phosphorylation and activation of the latent transcription factor Stat3 in HepG2 cells. Mutation of Stat3 tyrosine 705 to phenylalanine (Y705F) inhibits IL-6-induced tyrosine phosphorylation of this Stat3 mutant in transfected HepG2 cells. In cotransfections of HepG2 cells, the Stat3 mutant Y705F causes a reduction of the tyrosine phosphorylation of wild type Stat3-FLAG....

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Identifiers

PMID: 8626374
DOI: 10.1074/jbc.271.11.5961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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