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Article

Noncanonical pS727 post translational modification dictates major STAT3 activation and downstream functions in breast cancer.

Experimental cell research - 15 Nov 2020

Dimri Shalini, Malhotra Renu, Shet Tanuja, Mokal Smruti, Gupta Sudeep, De Abhijit

Abstract excerpt

Activation of STAT3 via Y705-phosphorylation is well documented across multiple cancer types and thus forms the basis of canonical pathway to judge STAT3 activation. Recently, important roles of two other post translational modification (PTM) sites, i.e. S727-phosphorylation and K685-acetylation, leading to STAT3 activation are reported. However, their critical mode of function in controlling STAT3 dimerization...

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Identifiers

PMID: 33002501
DOI: 10.1016/j.yexcr.2020.112313

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