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Iron induced RNA-oxidation in the general population and in mouse tissue.

Free radical biology & medicine - 1 Feb 2018

Cejvanovic Vanja, Kjær Laura Kofoed, Bergholdt Helle Kirstine Mørup, Torp-Pedersen Arendse, Henriksen Trine, Weimann Allan, Ellervik Christina, Poulsen Henrik Enghusen

Abstract excerpt

Iron promotes formation of hydroxyl radicals by the Fenton reaction, subsequently leading to potential oxidatively generated damage of nucleic acids. Oxidatively generated damage to RNA, measured as 8-oxo-7,8-dihydroguanosine (8-oxoGuo) in urine, is increased in patients with genetic iron overload, which have led us to test the hypothesis that high iron status, assessed by iron biomarkers and genetic disposition,...

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Identifiers

PMID: 29157668
DOI: 10.1016/j.freeradbiomed.2017.11.013

Genes

HFE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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