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Article

8-oxoguanine causes spontaneous de novo germline mutations in mice.

Scientific reports - 15 Apr 2014

Ohno Mizuki, Sakumi Kunihiko, Fukumura Ryutaro, Furuichi Masato, Iwasaki Yuki, Hokama Masaaki, Ikemura Toshimichi, Tsuzuki Teruhisa, Gondo Yoichi, Nakabeppu Yusaku

Abstract excerpt

Spontaneous germline mutations generate genetic diversity in populations of sexually reproductive organisms, and are thus regarded as a driving force of evolution. However, the cause and mechanism remain unclear. 8-oxoguanine (8-oxoG) is a candidate molecule that causes germline mutations, because it makes DNA more prone to mutation and is constantly generated by reactive oxygen species in vivo. We show here that...

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Source

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Identifiers

PMID: 24732879
DOI: 10.1038/srep04689
PMCID: PMC3986730

Genes

MUTYH
OGG1

Provenance

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