Article
Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases.
Proceedings of the National Academy of Sciences of the United States of America - 7 Nov 2000
Hussain S P, Raja K, Amstad P A, Sawyer M, Trudel L J, Wogan G N, Hofseth L J, Shields P G, Billiar T R, Trautwein C, Hohler T, Galle P R, Phillips D H, Markin R, Marrogi A J, Harris C C
Abstract excerpt
Hemochromatosis and Wilson disease (WD), characterized by the excess hepatic deposition of iron and copper, respectively, produce oxidative stress and increase the risk of liver cancer. Because the frequency of p53 mutated alleles in nontumorous human tissue may be a biomarker of oxyradical damage and identify individuals at increased cancer risk, we have determined the frequency of p53 mutated alleles in...
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