Genetic effects of iron levels on liver injury and risk of liver diseases: A two-sample Mendelian randomization analysis

Abstract excerpt

Background and aims: Although iron homeostasis has been associated with liver function in many observational studies, the causality in this relationship remains unclear. By using Mendelian Randomization analyses, we aimed to evaluate the genetic effects of increased systemic iron levels on the risk of liver injury and various liver diseases. Moreover, in light of the sex-dependent iron regulation in human beings,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic Associations and Epidemiology
• Share to Hemoglobinopathies and Related Disorders
• Share to Iron Metabolism and Disorders