Article
Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population.
Journal of neurology, neurosurgery, and psychiatry - 1 Jan 2011
Schuur M, van Swieten J C, Schol-Gelok S, Ikram M A, Vernooij M W, Liu F, Isaacs A, de Boer R, de Koning I, Niessen W J, Vrooman H, Oostra B A, van der Lugt A, Breteler M M B, van Duijn C M
Abstract excerpt
BACKGROUND: Asymptomatic cerebral lesions on MRI such as white matter lesions (WML), lacunes and microbleeds are commonly seen in older people. We examined the role of a series of candidate genes involved in blood pressure regulation and amyloid metabolism. MATERIALS AND METHODS: The study was embedded in a family-based cohort sampled from a Dutch genetically isolated population. We selected individuals between...
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