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Article

APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds.

International journal of stroke : official journal of the International Stroke Society - 1 Dec 2015

Lyall Donald M, Muñoz Maniega Susana, Harris Sarah E, Bastin Mark E, Murray Catherine, Lutz Michael W, Saunders Ann M, Roses Allen D, Valdés Hernández Maria del C, Royle Natalie A, Starr John M, Porteous David J, Deary Ian J, Wardlaw Joanna M

Abstract excerpt

BACKGROUND: Two markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease. AIM AND/OR HYPOTHESIS: To test for independent associations between two Alzheimer's disease-susceptibility gene loci--APOE ε and the TOMM40 '523' poly-T repeat--and white matter hyperintensities/cerebral microbleed burden in...

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Identifiers

PMID: 26310205
DOI: 10.1111/ijs.12615
PMCID: PMC4950052

Genes

APOE
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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