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Article

Parental History of Dementia Is Associated with Increased Small Vessel Cerebrovascular Disease.

The journals of gerontology. Series A, Biological sciences and medical sciences - 15 Oct 2020

Stamm Bessie C, Lao Patrick J, Rizvi Batool, Colon Juliet, Igwe Kay, Chesebro Anthony G, Maas Benjamin, Schupf Nicole, Mayeux Richard, Manly Jennifer J, Brickman Adam M

Abstract excerpt

BACKGROUND: Small vessel cerebrovascular dysfunction that manifests on magnetic resonance imaging (MRI) as white matter hyperintensities (WMH) is linked to increased risk and progression of Alzheimer's disease (AD), but there is considerable debate about whether it represents a core feature of the disease. Parental history of dementia is a risk factor for AD, suggesting a strong heritable component; the...

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Identifiers

PMID: 31838489
DOI: 10.1093/gerona/glz291
PMCID: PMC7566406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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