Genetics of Parkinson's disease and related disorders.

doi:10.1136/jmedgenet-2017-105047

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Article

Genetics of Parkinson's disease and related disorders.

Journal of medical genetics - 1 Feb 2018

Zhang Pei-Lan, Chen Yan, Zhang Chen-Hao, Wang Yu-Xin, Fernandez-Funez Pedro

Abstract excerpt

Parkinson's disease (PD) is a complex and heterogeneous neurological condition characterised mainly by bradykinesia, resting tremor, rigidity and postural instability, symptoms that together comprise the parkinsonian syndrome. Non-motor symptoms preceding and following clinical onset are also helpful diagnostic markers revealing a widespread and progressive pathology. Many other neurological conditions also...

Topics

Dopamine
Genes, Dominant
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Mitochondria
Mutation
Neurons
Parkinson Disease
Parkinsonian Disorders
alpha-Synuclein
tau Proteins

Source

Open in PubMed

Identifiers

PMID: 29151060
DOI: 10.1136/jmedgenet-2017-105047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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