Article
The genetics of Parkinson disease.
Ageing research reviews - 1 Mar 2018
Deng Hao, Wang Peng, Jankovic Joseph
Abstract excerpt
About 15% of patients with Parkinson disease (PD) have family history and 5-10% have a monogenic form of the disease with Mendelian inheritance. To date, at least 23 loci and 19 disease-causing genes for parkinsonism have been found, but many more genetic risk loci and variants for sporadic PD phenotype have been identified in various association studies. Investigating the mutated protein products has uncovered...
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