Article
Updates on the Genetics of Parkinson's Disease: Clinical Implications and Future Treatment.
Acta neurologica Taiwanica - 30 Sept 2021
Chu Yung-Tsai, Tai Chun-Hwei, Lin Chin-Hsien, Wu Ruey-Meei
Abstract excerpt
Parkinson' disease (PD) is a common neurodegenerative disease with the pathological hallmark of alpha-synuclein aggregation within dopaminergic neurons. The etiology of PD comes from a complex interplay between genetic and environmental factors. Though most cases of PD are sporadic; a family history of PD is found in approximately 15% of patients. Pathogenic mutations are found in 5% to 10% of individuals with...
Topics
- Humans
- Mutation
- Neurodegenerative Diseases
- Parkinson Disease
- alpha-Synuclein