Article
The genetics of Parkinson disease.
Journal of geriatric psychiatry and neurology - 1 Dec 2010
Bekris Lynn M, Mata Ignacio F, Zabetian Cyrus P
Abstract excerpt
Parkinson disease (PD) is the second most common neurodegenerative disorder. In most instances, PD is thought to result from a complex interaction between multiple genetic and environmental factors, though rare monogenic forms of the disease do exist. Mutations in 6 genes (SNCA, LRRK2, PRKN, DJ1, PINK1, and ATP13A2) have conclusively been shown to cause familial parkinsonism. In addition, common variation in 3...
Topics
- Aging
- Animals
- Calcium-Binding Proteins
- Carrier Proteins
- Exons
- Gene Expression
- Genetic Predisposition to Disease
- Genetic Variation
- Glucosylceramidase
- Humans
- Incidence
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2