Article
Parkinson's disease: genetics and pathogenesis.
Annual review of pathology - 1 Jan 2011
Shulman Joshua M, De Jager Philip L, Feany Mel B
Abstract excerpt
Recent investigation into the mechanisms of Parkinson's disease (PD) has generated remarkable insight while simultaneously challenging traditional conceptual frameworks. Although the disease remains defined clinically by its cardinal motor manifestations and pathologically by midbrain dopaminergic cell loss in association with Lewy bodies, it is now recognized that PD has substantially more widespread impact,...
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