Article
Genetics of Parkinson's disease and parkinsonism.
Expert review of neurotherapeutics - 1 Jun 2007
Douglas Michael R, Lewthwaite Alistair J, Nicholl David J
Abstract excerpt
The past 10 years has seen a shift in our etiological concepts of Parkinson's disease, moving from a nearly exclusively environmentally mediated disease towards a complex disorder with important genetic contributors. The identification of responsible mutations in certain genes, particularly alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, has increased our understanding of the clinical and pathological changes...
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