Genetics of Parkinson's disease and parkinsonism.

doi:10.1586/14737175.7.6.657

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Article

Genetics of Parkinson's disease and parkinsonism.

Expert review of neurotherapeutics - 1 Jun 2007

Douglas Michael R, Lewthwaite Alistair J, Nicholl David J

Abstract excerpt

The past 10 years has seen a shift in our etiological concepts of Parkinson's disease, moving from a nearly exclusively environmentally mediated disease towards a complex disorder with important genetic contributors. The identification of responsible mutations in certain genes, particularly alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, has increased our understanding of the clinical and pathological changes...

Topics

Brain
Clinical Trials as Topic
Genes, Dominant
Genes, Recessive
Genetic Predisposition to Disease
Genetic Therapy
Humans
Intracellular Signaling Peptides and Proteins
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Oncogene Proteins
Parkinson Disease
Protein Deglycase DJ-1
Protein Kinases
Protein Serine-Threonine Kinases
Ubiquitin-Protein Ligases
alpha-Synuclein

Source

Open in PubMed

Identifiers

PMID: 17563249
DOI: 10.1586/14737175.7.6.657

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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