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Article

The role of exon sequences in C complex spliceosome structure.

Journal of molecular biology - 27 Nov 2009

Ilagan Janine, Yuh Patrick, Chalkley Robert J, Burlingame A L, Jurica Melissa S

Abstract excerpt

Pre-mRNA splicing is catalyzed by a large ribonucleoprotein complex called the spliceosome. Previous electron microscopy reconstruction of C complex spliceosomes arrested between the two chemical steps of splicing revealed an averaged core structure consisting of three primary domains surrounding a central cavity. Here we characterize the involvement of pre-mRNA in this structured core of C complex by protection...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19761775
DOI: 10.1016/j.jmb.2009.09.019
PMCID: PMC2783800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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