Article
The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.
Science (New York, N.Y.) - 17 Nov 2017
Tenthorey Jeannette L, Haloupek Nicole, López-Blanco José Ramón, Grob Patricia, Adamson Elise, Hartenian Ella, Lind Nicholas A, Bourgeois Natasha M, Chacón Pablo, Nogales Eva, Vance Russell E
Abstract excerpt
Robust innate immune detection of rapidly evolving pathogens is critical for host defense. Nucleotide-binding domain leucine-rich repeat (NLR) proteins function as cytosolic innate immune sensors in plants and animals. However, the structural basis for ligand-induced NLR activation has so far remained unknown. NAIP5 (NLR family, apoptosis inhibitory protein 5) binds the bacterial protein flagellin and assembles...
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