Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity.

PLoS pathogens - 1 Mar 2006

Ren Tao, Zamboni Dario S, Roy Craig R, Dietrich William F, Vance Russell E

Abstract excerpt

Macrophages from C57BL/6J (B6) mice restrict growth of the intracellular bacterial pathogen Legionella pneumophila. Restriction of bacterial growth requires caspase-1 and the leucine-rich repeat-containing protein Naip5 (Birc1e). We identified mutants of L. pneumophila that evade macrophage innate immunity. All mutants were deficient in expression of flagellin, the primary flagellar subunit, and failed to induce...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 1
Share to Cell Death
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Flagellin

Share to Immunity

Share to Macrophages

Share to Salmonella

Share to Toll-Like Receptor 5

Source

Open in PubMed Open full text

Identifiers

PMID: 16552444
DOI: 10.1371/journal.ppat.0020018
PMCID: PMC1401497

Genes

TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity.PMID 16552444Read ↗

The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation.Semantic proximity Read ↗

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila.Semantic proximity Read ↗

Innate immune detection of flagellin positively and negatively regulates salmonella infection.Semantic proximity Read ↗

Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis.Semantic proximity Read ↗

Global cellular changes induced by Legionella pneumophila infection of bone marrow-derived macrophages.Semantic proximity Read ↗

Innate immune recognition of flagellin limits systemic persistence of Brucella.Semantic proximity Read ↗

Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.Semantic proximity Read ↗

Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection.Semantic proximity Read ↗

The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.Semantic proximity Read ↗

Escape of TLR5 Recognition by <i>Leptospira spp</i> : A Rationale for Atypical EndoflagellaSemantic proximity Read ↗

Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila.Semantic proximity Read ↗

Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.