Article
Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells.
Nature communications - 9 Oct 2019
Liu Chang, Tate Tiffany, Batourina Ekatherina, Truschel Steven T, Potter Steven, Adam Mike, Xiang Tina, Picard Martin, Reiley Maia, Schneider Kerry, Tamargo Manuel, Lu Chao, Chen Xiao, He Jing, Kim Hyunwoo, Mendelsohn Cathy Lee
Abstract excerpt
The urothelium is an epithelial barrier lining the bladder that protects against infection, fluid exchange and damage from toxins. The nuclear receptor Pparg promotes urothelial differentiation in vitro, and Pparg mutations are associated with bladder cancer. However, the function of Pparg in the healthy urothelium is unknown. Here we show that Pparg is critical in urothelial cells for mitochondrial biogenesis,...
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