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Article

Repression of transcription factor AP-2 alpha by PPARγ reveals a novel transcriptional circuit in basal-squamous bladder cancer

26 Nov 2019

Abstract excerpt

The discovery of bladder cancer transcriptional subtypes provides an opportunity to identify high risk patients, and tailor disease management. Recent studies suggest tumor heterogeneity contributes to regional differences in molecular subtype within the tumor, as well as during progression and following treatment. Nonetheless, the transcriptional drivers of the aggressive basal-squamous subtype remain...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 31772149
DOI: 10.1038/s41389-019-0178-3

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