Article
Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus.
Nature communications - 15 Nov 2017
Schulz Herbert, Ruppert Ann-Kathrin, Herms Stefan, Wolf Christiane, Mirza-Schreiber Nazanin, Stegle Oliver, Czamara Darina, Forstner Andreas J, Sivalingam Sugirthan, Schoch Susanne, Moebus Susanne, Pütz Benno, Hillmer Axel, Fricker Nadine, Vatter Hartmut, Müller-Myhsok Bertram, Nöthen Markus M, Becker Albert J, Hoffmann Per, Sander Thomas, Cichon Sven
Abstract excerpt
Emerging evidence emphasizes the strong impact of regulatory genomic elements in neurodevelopmental processes and the complex pathways of brain disorders. The present genome-wide quantitative trait loci analyses explore the cis-regulatory effects of single-nucleotide polymorphisms (SNPs) on DNA methylation (meQTL) and gene expression (eQTL) in 110 human hippocampal biopsies. We identify cis-meQTLs at 14,118 CpG...
Topics
- Adolescent
- Adult
- Aged
- Child
- Child, Preschool
- DNA Methylation
- Epilepsy, Temporal Lobe
- Female
- Gene Expression Profiling