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Article

The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484.

Open biology - 1 Nov 2017

Bradshaw Nicholas J, Ukkola-Vuoti Liisa, Pankakoski Maiju, Zheutlin Amanda B, Ortega-Alonso Alfredo, Torniainen-Holm Minna, Sinha Vishal, Therman Sebastian, Paunio Tiina, Suvisaari Jaana, Lönnqvist Jouko, Cannon Tyrone D, Haukka Jari, Hennah William

Abstract excerpt

Genetic studies of familial schizophrenia in Finland have observed significant associations with a group of biologically related genes, DISC1, NDE1, NDEL1, PDE4B and PDE4D, the 'DISC1 network'. Here, we use gene expression and psychoactive medication use data to study their biological consequences and potential treatment implications. Gene expression levels were determined in 64 individuals from 18 families,...

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Identifiers

PMID: 29142105
DOI: 10.1098/rsob.170153
PMCID: PMC5717342

Genes

NDE1
DISC1
NDEL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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