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Article

A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis.

PLoS pathogens - 1 Jul 2014

Newton Hayley J, Kohler Lara J, McDonough Justin A, Temoche-Diaz Morayma, Crabill Emerson, Hartland Elizabeth L, Roy Craig R

Abstract excerpt

Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-derived vacuole. The molecular mechanisms used by this bacterium to create a pathogen-occupied vacuole remain largely unknown. Here, we conducted a visual screen on an arrayed library of C. burnetii NMII transposon insertion mutants to identify genes required for biogenesis of a mature Coxiella-containing vacuole (CCV). Mutants defective...

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Identifiers

PMID: 25080348
DOI: 10.1371/journal.ppat.1004286
PMCID: PMC4117601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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