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Article

Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2014

Peterson David, Munger Caitlin, Crowley Jared, Corcoran Chris, Cruchaga Carlos, Goate Alison M, Norton Maria C, Green Robert C, Munger Ronald G, Breitner John C S, Welsh-Bohmer Kathleen A, Lyketsos Constantine, Tschanz Joann, Kauwe John S K

Abstract excerpt

BACKGROUND: Single-nucleotide polymorphisms (SNPs) located in the gene encoding the regulatory subunit of the protein phosphatase 2B (PPP3R1, rs1868402) and the microtubule-associated protein tau (MAPT, rs3785883) gene were recently associated with higher cerebrospinal fluid (CSF) tau levels in samples from the Knight Alzheimer's Disease Research Center at Washington University (WU) and Alzheimer's Disease...

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Identifiers

PMID: 23727081
DOI: 10.1016/j.jalz.2013.02.010
PMCID: PMC3809344

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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