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Article

A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites.

European biophysics journal : EBJ - 1 Apr 2008

Laver Derek R, Honen Bonny N, Lamb Graham D, Ikemoto Noriaki

Abstract excerpt

The clustering of cardiac RyR mutations, linked to sudden cardiac death (SCD), into several regions in the amino acid sequence underlies the hypothesis that these mutations interfere with stabilising interactions between different domains of the RyR2. SCD mutations cause increased channel sensiti...

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Source

Identifiers

PMID: 18038129
DOI: 10.1007/s00249-007-0238-z

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18038129-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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